Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP19 | O94966 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526701 | 0.89 | USP19 (0.49) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3622805 | 0.81 | MEN1 (0.51) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL7668679 | 0.80 | USP19 (0.46) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL16475199 | 0.80 | TMEM97 (0.52) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL4391159 | 0.80 | MEN1 (0.50) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL28429220 | 0.79 | USP19 (0.49) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3902852 | 0.78 | SMN1; SMN2 (0.56) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL28429226 | 0.78 | MEN1 (0.48) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL28433633 | 0.78 | P2RX7 (0.49) | USP19SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8386105 | 0.77 | KMT2A (0.52) | USP19SMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335343-B1 | IMIDAZOL-5-YLALKYLPIPERIZINE DERIVATIVES; ANTICARCINOGENIC AGENTS | MERCK & CO., INC. | 2002-01-01 | — | — | US | disclosed |