SCHEMBL7527600

SCHEMBL7527600

O=CNc1cccc(C(F)(F)F)c1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 4/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
CTSS P25774 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
SLC22A12 Q96S37 1/20 0.38
ULK1 O75385 1/20 0.38
KDM4E B2RXH2 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
TAS1R2 Q8TE23 1/20 0.37
EGFR P00533 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2096095 0.82 POLB (0.53) RXFP1ALDH1A1POLBTDP1L3MBTL1
SCHEMBL8952231 0.80 TAS2R14 (0.51) CTSSRXFP1ALDH1A1POLBTDP1
SCHEMBL29542656 0.80 RXFP1 (0.40) RXFP1ALDH1A1POLBTDP1L3MBTL1
SCHEMBL11616035 0.76 ALDH1A1 (0.38) CTSSRXFP1ALDH1A1POLBTDP1
SCHEMBL2090488 0.76 TSHR (0.40) RXFP1ALDH1A1POLBKDM4EMEN1
SCHEMBL5624233 0.75 RXFP1 (0.48) EPHX2CA12CA1CA2CA9
SCHEMBL11404399 0.75 EPHX2 (0.48) EPHX2CA12CA1CA2CA9
SCHEMBL3872255 0.75 EPHX2 (0.46) EPHX2CA12CA1CA2CA9
SCHEMBL31646292 0.75 EPHX2 (0.46) EPHX2CA12CA1CA2CA9
SCHEMBL7527595 0.74 EPHX2 (0.44) EPHX2CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP claimed
US-6362342-B1 BIOSYNTHESIS; DRUG LIBRARIES LION BIOSCIENCE AG (DE) 2002-03-26 US claimed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO claimed
EP-3013798-B1 FUSED TRICYCLIC UREA COMPOUNDS AS RAF KINASE AND/OR RAF KINASE DIMER INHIBITORS BEIGENE LTD (KY) 2018-06-27 EP disclosed
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP disclosed
US-6362342-B1 BIOSYNTHESIS; DRUG LIBRARIES LION BIOSCIENCE AG (DE) 2002-03-26 US disclosed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO disclosed
US-5518994-A 2-arylaminopyrimidinone derivative, and herbicide and plant growth regulator NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-21 US disclosed
EP-0636615-A1 2-ARYLAMINOPYRIMIDINONE DERIVATIVE, AND HERBICIDE AND PLANT GROWTH REGULATOR NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1995-02-01 EP disclosed