SCHEMBL7529202

SCHEMBL7529202

Clc1ccc2c(Oc3ccnc4cc(Cl)ccc34)ccnc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 2/20 0.59
SOS2 Q07890 1/20 0.59
LMNA P02545 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
MAPT P10636 3/20 0.54
ALDH1A1 P00352 1/20 0.54
GLA P06280 1/20 0.54
HPGD P15428 1/20 0.54
TSHR P16473 1/20 0.54
MAPK1 P28482 1/20 0.54
CYP1A2 P05177 1/20 0.53
APP P05067 2/20 0.52
HSD17B10 Q99714 2/20 0.51
KMT2A Q03164 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
CCR1 P32246 1/20 0.50
PKM P14618 1/20 0.50
ALOX15 P16050 1/20 0.50
CASP1 P29466 1/20 0.50
CHKA P35790 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7462623 0.90 LMNA (0.54) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7464868 0.89 MAPT (0.54) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL1702115 0.87 LMNA (0.61) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7463576 0.87 APP (0.52) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7461008 0.86 NPC1 (0.58) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7468141 0.86 APP (0.49) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7458619 0.86 APP (0.52) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7466204 0.86 APP (0.49) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL7464969 0.86 APP (0.49) NR4A2SOS2LMNASMN1; SMN2MAPT
SCHEMBL27312782 0.86 APP (0.49) NR4A2SOS2LMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed
CN-1031263-C Quinoline, quinazoline, and cinnoline LILLY CO ELI (US) 1996-03-13 CN disclosed
US-5296484-A Applying fungicide to locus of plant pathogen DOWELANCO (US) 1994-03-22 US disclosed
US-5240940-A Synergistic nmixture DOWELANCO (US) 1993-08-31 US disclosed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US disclosed
CN-1034924-A quinoline, quinazoline and cinnoline derivatives LILLY CO ELI (US) 1989-08-23 CN disclosed
CN-1034925-A Quinoline, quinazoline and cinnoline LILLY CO ELI (US) 1989-08-23 CN disclosed
EP-0326330-A2 Quinoline, quinazoline, and cinnoline fungicides DowElanco (US) 1989-08-02 EP disclosed
EP-0326328-A2 Quinoline, quinazoline, and cinnoline derivatives DowElanco (US) 1989-08-02 EP disclosed