Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Carbromal. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbromal SCHEMBL11332793 | 0.97 | CRBN (0.30) | CRBN | |
| Carbromal SCHEMBL8594411 | 0.97 | MMP1 (0.32) | CRBN | |
| Carbromal SCHEMBL1499641 | 0.95 | SLC34A1 (0.32) | CRBN | |
| Carbromal SCHEMBL10866938 | 0.93 | SLC34A1 (0.31) | CRBN | |
| Carbromal SCHEMBL995158 | 0.93 | MMP1 (0.32) | CRBN | |
| Carbromal SCHEMBL10792521 | 0.92 | MMP1 (0.31) | — | |
| Carbromal SCHEMBL20187681 | 0.91 | CRBN (0.31) | CRBN | |
| Carbromal SCHEMBL11337617 | 0.91 | CRBN (0.31) | CRBN | |
| Carbromal SCHEMBL10494453 | 0.91 | CRBN (0.31) | CRBN | |
| Carbromal SCHEMBL620919 | 0.91 | CRBN (0.33) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913213-B1 | Metalworking method | GIRARDELLO PIERANGELO (IT) | 2002-04-10 | — | — | EP | claimed |
| US-6098436-A | Metalworking method and product obtained with the method | GIRARDELLO PIERANGELO (IT) | 2000-08-08 | — | — | US | claimed |
| EP-0913213-A1 | Metalworking method and product obtained with the method | Girardello, Pierangelo (IT) | 1999-05-06 | — | — | EP | claimed |
| US-6474127-B1 | Pressing method, in particular for obtaining hydraulic cylinders and high-pressure filters | EDMONTON CONSULTADORIA E SERVICIOS LDA (PG) | 2002-11-05 | — | — | US | disclosed |
| EP-0913213-B1 | Metalworking method | GIRARDELLO PIERANGELO (IT) | 2002-04-10 | — | — | EP | disclosed |
| US-6098436-A | Metalworking method and product obtained with the method | GIRARDELLO PIERANGELO (IT) | 2000-08-08 | — | — | US | disclosed |
| EP-0913213-A1 | Metalworking method and product obtained with the method | Girardello, Pierangelo (IT) | 1999-05-06 | — | — | EP | disclosed |