Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 3/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528581 | 0.92 | ESR1 (0.41) | ESR1ESR2HRH3CHRNB4CHRNA3 | |
| SCHEMBL7529441 | 0.89 | ESR1 (0.49) | ESR1ESR2HRH3CHRNB4CHRNA3 | |
| SCHEMBL7527322 | 0.85 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL7145058 | 0.80 | EBP (0.40) | ESR1ESR2HRH3CHRNB4CHRNA3 | |
| SCHEMBL7531753 | 0.79 | ESR1 (0.46) | ESR1ESR2HRH3CHRNB4CHRNA3 | |
| SCHEMBL7532152 | 0.78 | ESR1 (0.56) | ESR1ESR2HRH3 | |
| SCHEMBL7535261 | 0.77 | ESR1 (0.57) | ESR1ESR2HRH3 | |
| SCHEMBL7530105 | 0.76 | PTPN1 (0.41) | ESR1ESR2 | |
| SCHEMBL7144464 | 0.76 | CHRM3 (0.39) | ESR1CHRNB4CHRNA3CHRM3CHEK1 | |
| SCHEMBL7528598 | 0.73 | ESR1 (0.67) | ESR1ESR2HRH3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |