SCHEMBL7531040

SCHEMBL7531040

COC(=O)CCc1cc(O)c(OC)cc1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.38
BACE1 P56817 1/20 0.36
TRPV1 Q8NER1 5/20 0.36
CYP1A2 P05177 2/20 0.36
CYP3A4 P08684 2/20 0.36
CYP2D6 P10635 2/20 0.36
HPGD P15428 2/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TP53 P04637 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
ALOX5 P09917 1/20 0.35
OR51E2 Q9H255 1/20 0.35
KDM4E B2RXH2 1/20 0.34
APEX1 P27695 1/20 0.34
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7530218 0.94 HMGCR (0.41) HMGCRBACE1TRPV1CYP1A2CYP3A4
SCHEMBL8959275 0.91 HMGCR (0.41) HMGCRBACE1TRPV1PDE4DPOLB
SCHEMBL7530400 0.87 MTNR1A (0.36) HMGCRBACE1TRPV1CYP1A2CYP3A4
SCHEMBL7529985 0.86 TNFSF11 (0.39) HMGCRBACE1CYP3A4HPGDTSHR
SCHEMBL7532530 0.86 BACE1 (0.36) BACE1ALDH1A1KDM4EMTNR1AMTNR1B
SCHEMBL7530899 0.86 MTNR1A (0.38) HMGCRBACE1TRPV1CYP1A2CYP3A4
SCHEMBL7534945 0.86 MTNR1A (0.38) HMGCRBACE1TRPV1CYP1A2CYP3A4
SCHEMBL7532277 0.86 MTNR1A (0.38) HMGCRBACE1TRPV1CYP1A2CYP3A4
SCHEMBL7536283 0.82 HMGCR (0.36) HMGCRBACE1HPGDALDH1A1MTNR1A
SCHEMBL7536742 0.82 MTNR1A (0.39) BACE1TRPV1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0585371-B1 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE POULENC RORER INTERNAT H (US) 2002-04-17 EP disclosed
US-5571506-A AROMATIC ALDEHYDE OLIGOMERS FOR TREATMENT OF CARDIOVASCULAR DISORDERS, BONE METABOLISM, ANTILIPEMIC AGENTS AND GASTROINTESTINAL DISORDERS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-11-05 US disclosed
EP-0585371-A4 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE POULENC RORER INT (US) 1994-07-13 EP disclosed
EP-0585371-A1 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1994-03-09 EP disclosed
WO-1992020350-A1 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-11-26 WO disclosed