Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.75 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Penicillamine SCHEMBL952027 | 0.87 | ALDH1A1 (0.90) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Penicillamine SCHEMBL952026 | 0.87 | ALDH1A1 (0.90) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Dl-Penicillamine SCHEMBL159653 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Dl-Penicillamine SCHEMBL22322162 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Penicillamine SCHEMBL4343 | 0.87 | — | — | |
| Penicillamine SCHEMBL129296 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Dl-Penicillamine SCHEMBL57527 | 0.87 | — | — | |
| Dl-Penicillamine SCHEMBL4344 | 0.87 | — | — | |
| Penicillamine SCHEMBL603349 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Dl-Penicillamine SCHEMBL7932150 | 0.84 | ALDH1A1 (0.95) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156134-A1 | Method and use of alpha-amino-beta-mercapto-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage | JACOBSON ELAINE L (US) | 2002-10-24 | — | — | US | disclosed |
| US-6417235-B2 | INHIBITING PRODUCTION OF ADVANCED GLYCOSYLATION END PRODUCTS IN A PATIENT COMPRISING ADMINISTERING TO THE PATIENT D-PENICILLAMINE, L-PENICILLAMINE, AND D,L-PENICILLAMINE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2002-07-09 | — | — | US | disclosed |
| US-20010051658-A1 | Method and use of penicillamines and other alpha-amino-beta,beta-mercapto-beta,beta-dimethyl-ethane derivatives as dicarbonyl scavengers for treatment of conditions resulting from protein, lipid, and DNA damage | NIADYNE, INC. | 2001-12-13 | — | — | US | disclosed |