Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28950911 | 1.00 | OPRM1 (0.42) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL7778240 | 1.00 | OPRM1 (0.42) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL13500020 | 1.00 | OPRM1 (0.42) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL17253408 | 1.00 | OPRM1 (0.42) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL7777210 | 1.00 | OPRM1 (0.42) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL11234095 | 0.98 | OPRM1 (0.44) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL96052 | 0.92 | TDP1 (0.41) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL4022359 | 0.91 | DNM1 (0.48) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL19219115 | 0.91 | DNM1 (0.48) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL3039218 | 0.91 | DNM1 (0.48) | OPRM1FAAHCNR1CNR2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | disclosed |