Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1350281 | 0.97 | CA2 (0.47) | CA2RECQLCYP3A4TSHRTDP1 | |
| SCHEMBL4961431 | 0.88 | RECQL (0.39) | CA2RECQLCYP3A4TSHRTDP1 | |
| SCHEMBL10420759 | 0.81 | CA2 (0.46) | CA2RECQLCYP3A4TSHRTDP1 | |
| SCHEMBL5254621 | 0.78 | CA2 (0.51) | CA2RECQLCYP3A4TSHRTDP1 | |
| SCHEMBL1423320 | 0.77 | CA2 (0.57) | CA2CYP3A4TSHRTDP1ATM | |
| Lithium Ion SCHEMBL6258171 | 0.76 | CES2 (0.37) | ATML3MBTL1 | |
| Lithium Ion SCHEMBL6258184 | 0.76 | CES2 (0.37) | ATML3MBTL1 | |
| SCHEMBL1984429 | 0.76 | CES2 (0.37) | RECQLTSHRATML3MBTL1CA1 | |
| SCHEMBL788087 | 0.76 | CES2 (0.37) | RECQLTSHRATML3MBTL1CA1 | |
| SCHEMBL486057 | 0.76 | CES2 (0.37) | RECQLTSHRATML3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857578-B1 | Thermal head assembly comprising a plurality of thermal heads | AGFA GEVAERT (BE) | 2002-03-13 | — | — | EP | disclosed |
| US-6028618-A | Thermal printing head coating | AGFA-GEVAERT (BE) | 2000-02-22 | — | — | US | disclosed |
| EP-0860288-A1 | Thermal printing head coating | AGFA-GEVAERT N.V. (BE) | 1998-08-26 | — | — | EP | disclosed |