Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.51 |
| ▸ | PDE4A | P27815 | 15/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8677454 | 0.92 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL7858805 | 0.89 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL8677452 | 0.88 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL7792800 | 0.88 | CASP1 (0.42) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL5703639 | 0.87 | PDE4B (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7866895 | 0.84 | PDE4B (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7421932 | 0.81 | CASP1 (0.53) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL5498121 | 0.80 | PDE4B (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL5498116 | 0.79 | PDE4B (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27617802 | 0.79 | PDE4B (0.46) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636025-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-07-18 | — | — | EP | disclosed |
| US-5449686-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0636025-A4 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES. | — | 1995-02-22 | — | — | EP | disclosed |
| EP-0636025-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993019750-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | disclosed |