Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 11/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421932 | 0.93 | CASP1 (0.53) | CASP1HSD17B10PDE4APDE4BPDE4C | |
| SCHEMBL7532617 | 0.88 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL7866895 | 0.87 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7415171 | 0.86 | HSD17B10 (0.45) | CASP1HSD17B10PDE4APDE4BPDE4C | |
| SCHEMBL7416817 | 0.82 | HSD17B10 (0.52) | CASP1HSD17B10FFAR1L3MBTL1CYP3A4 | |
| SCHEMBL7384417 | 0.80 | HSD17B10 (0.66) | CASP1HSD17B10L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL8677454 | 0.80 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL8677452 | 0.77 | PDE4D (0.45) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL7858805 | 0.76 | PDE4D (0.48) | CASP1HSD17B10PDE4APDE4BPDE4C | |
| SCHEMBL7865357 | 0.76 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | disclosed |
| US-5605923-A | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |