Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TST | Q16762 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185190 | 0.93 | ALDH1A1 (0.43) | HTR2AALDH1A1 | |
| SCHEMBL29218752 | 0.81 | SPHK1 (0.56) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL11166115 | 0.81 | BCHE (0.57) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL24760394 | 0.79 | AKT1 (0.44) | — | |
| SCHEMBL10106667 | 0.79 | SLC6A4 (0.43) | SLC6A4SLC6A3 | |
| SCHEMBL9189454 | 0.77 | CA2 (0.40) | HTR2AALDH1A1LMNAHSD17B10 | |
| SCHEMBL22184019 | 0.77 | LPL (0.44) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL24760393 | 0.77 | AKT1 (0.45) | — | |
| SCHEMBL29218845 | 0.76 | SPHK1 (0.50) | HTR2AALDH1A1HSD17B10 | |
| SCHEMBL5681343 | 0.76 | EPHX1 (0.45) | HTR2AESR1ADRA2AADORA3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5239110-A | Phenylcyclohexanol derivatives as agents for treating CNS disorders | STERLING WINTHROP, INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0063793-A2 | (Arylmethyl)aryl-amino-cyclohexanols, -cyclohexanes, -cyclohexenes and intermediates thereof, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4313959-A | (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermediates thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-02-02 | — | — | US | disclosed |
| US-4313959-A | (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermediates thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-02-02 | — | — | US | disclosed |