Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PER2 | O15055 | 1/20 | 0.46 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284549 | 0.84 | MAPK14 (0.58) | GRM5 | |
| SCHEMBL25260183 | 0.84 | LMNA (0.64) | GRM5LMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL3054839 | 0.83 | GRM5 (0.67) | GRM5LMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL5946819 | 0.83 | GRM5 (0.67) | GRM5HRH3ACHE | |
| SCHEMBL12559545 | 0.83 | GRM5 (0.67) | GRM5LMNASMN1; SMN2HRH3HTT | |
| SCHEMBL29438631 | 0.83 | GRM5 (0.67) | GRM5LMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL5946784 | 0.83 | GRM5 (0.67) | GRM5LMNASMN1; SMN2L3MBTL1NCOA3 | |
| SCHEMBL8161846 | 0.83 | HRH3 (0.67) | GRM5DRD2HRH3DRD4DRD3 | |
| SCHEMBL29438656 | 0.83 | LMNA (0.60) | GRM5DRD2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL3372347 | 0.82 | GRM5 (0.52) | GRM5LMNASMN1; SMN2L3MBTL1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252161-A1 | PYRROLO-ISOQUINOLINE AND TETRAHYDROPYRROLO-ISOQUINOLINE DERIVATIVES AND THEIR USE AS MEDIATORS OF THE 5-HT7 RECEPTOR | Wyeth (US) | 2002-10-30 | — | — | EP | disclosed |
| US-6432974-B1 | CIRCADIAN RHYTHYM, SLEEP, SEXUAL, NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS; DRUG ABUSE, DRUG DEPENDENCE, AND SCHIZOPHRENIA TREATMENT | WYETH | 2002-08-13 | — | — | US | disclosed |
| WO-2001057039-A1 | PYRROLO-ISOQUINOLINE AND TETRAHYDROPYRROLO-ISOQUINOLINE DERIVATIVES AND THEIR USE AS MEDIATORS OF THE 5-HT7 RECEPTOR | WYETH (US) | 2001-08-09 | — | — | WO | disclosed |