Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309982 | 0.88 | LMNA (0.52) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL29438666 | 0.88 | LMNA (0.52) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL7533063 | 0.82 | GRM5 (0.67) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL29438656 | 0.82 | LMNA (0.60) | GRM5LMNASMN1; SMN2L3MBTL1HTT | |
| SCHEMBL25260183 | 0.78 | LMNA (0.64) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL27046207 | 0.78 | LMNA (0.43) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL16333639 | 0.77 | LMNA (0.49) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL8547964 | 0.76 | HRH3 (0.49) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL29438621 | 0.75 | GRM5 (0.49) | GRM5HRH3LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL4881755 | 0.75 | ITGB3 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |