Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 13/20 | 0.50 |
| ▸ | HTR7 | P34969 | 10/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570335 | 0.97 | HTR1A (0.48) | DRD2HTR1AHTR7KCNH2SLC6A4 | |
| SCHEMBL7532063 | 0.94 | HTR1A (0.48) | DRD2HTR1AHTR7SLC6A4DRD4 | |
| SCHEMBL7533277 | 0.93 | DRD2 (0.53) | DRD2HTR1AHTR7KCNH2SLC6A4 | |
| SCHEMBL7538517 | 0.90 | DRD2 (0.50) | DRD2HTR1AHTR7KCNH2SLC6A4 | |
| SCHEMBL7539800 | 0.88 | GAA (0.56) | DRD2HTR1AHTR7MPODRD4 | |
| SCHEMBL7532059 | 0.87 | HTR1A (0.56) | DRD2HTR1AHTR7KCNH2SLC6A4 | |
| SCHEMBL7534884 | 0.83 | DRD2 (0.47) | DRD2HTR1AHTR7SLC6A4ADRA1A | |
| SCHEMBL7532794 | 0.83 | GAA (0.55) | DRD2HTR1AHTR7SLC6A4ADRA1A | |
| SCHEMBL7538849 | 0.83 | GAA (0.52) | DRD2HTR1AKCNH2DRD4DRD3 | |
| SCHEMBL7532876 | 0.82 | HTR2A (0.49) | DRD2HTR1AHTR7DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | claimed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | claimed |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | disclosed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067237-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | DRD2 49/4885HTR1A 2/4885HTR7 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.