Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524797 | 0.78 | DGAT1 (0.40) | DGAT1CYP2A6PFKFB3 | |
| SCHEMBL31403102 | 0.77 | DGAT1 (0.41) | DGAT1IDO1 | |
| SCHEMBL22075678 | 0.76 | CYP11B1 (0.43) | DGAT1IDO1GSK3BDYRK1A | |
| SCHEMBL26693782 | 0.76 | CYP11B1 (0.51) | DGAT1APPIDO1 | |
| SCHEMBL7528332 | 0.76 | IDO1 (0.50) | CYP2A6IDO1WNT1GSK3BDYRK1A | |
| SCHEMBL23718770 | 0.75 | IDO1 (0.41) | DGAT1APPIDO1 | |
| SCHEMBL13070711 | 0.75 | DGAT1 (0.38) | DGAT1IDO1 | |
| SCHEMBL4062723 | 0.75 | CYP11B1 (0.50) | DGAT1IDO1 | |
| SCHEMBL203831 | 0.75 | CYP11B1 (0.48) | DGAT1IDO1 | |
| SCHEMBL4064922 | 0.75 | BRD9 (0.46) | QPCTAPPTDO2GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1193027-C | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2005-03-16 | — | — | CN | disclosed |
| CN-1411457-A | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2003-04-16 | — | — | CN | disclosed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |