Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 8/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527031 | 0.80 | HSD11B1 (0.42) | HSD11B1BRD4PFKFB3CYP2A6 | |
| SCHEMBL7843607 | 0.80 | ESR1 (0.47) | DGAT1BRD4PDE6D | |
| SCHEMBL1441203 | 0.79 | DGAT1 (0.46) | DGAT1BRD4PDE6D | |
| SCHEMBL2153326 | 0.79 | DGAT1 (0.40) | DGAT1BRD4PDE6D | |
| SCHEMBL7533347 | 0.78 | QPCT (0.39) | DGAT1PFKFB3CYP2A6 | |
| SCHEMBL9638271 | 0.78 | DGAT1 (0.41) | DGAT1 | |
| SCHEMBL18865495 | 0.77 | DGAT1 (0.39) | DGAT1BRD4PDE6DCYP2A6 | |
| SCHEMBL28937619 | 0.77 | DGAT1 (0.39) | DGAT1BRD4PDE6D | |
| SCHEMBL30615326 | 0.76 | DGAT1 (0.42) | DGAT1BRD4 | |
| SCHEMBL14812742 | 0.76 | DGAT1 (0.42) | DGAT1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1193027-C | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2005-03-16 | — | — | CN | disclosed |
| CN-1411457-A | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2003-04-16 | — | — | CN | disclosed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |