SCHEMBL7533402

SCHEMBL7533402

C[SiH](C)OCc1c(OC(=O)C(C)(C)C)ccc(Br)c1C(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ELANE P08246 18/20 0.36
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
CYP3A4 P08684 1/20 0.34
HIF1A Q16665 1/20 0.34
ADRB2 P07550 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4606175 0.68
SCHEMBL5715659 0.66 ELANE (0.40) ELANEALDH1A1LMNACYP3A4HIF1A
SCHEMBL28298353 0.64 PKM (0.62) ELANELMNA
SCHEMBL28869670 0.63 ELANE (0.62) ELANELMNA
SCHEMBL9309156 0.62 ABL1 (0.50) ELANEALDH1A1LMNACYP3A4HIF1A
SCHEMBL7112107 0.62 ELANE (0.41) ELANEALDH1A1LMNACYP3A4HIF1A
SCHEMBL9161988 0.62 CSNK2A1 (0.36) ALDH1A1
SCHEMBL6234126 0.61 PTGDR2 (0.38) ALDH1A1LMNAHIF1A
SCHEMBL6901839 0.61 CA2 (0.34)
SCHEMBL6751332 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0585371-B1 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE POULENC RORER INTERNAT H (US) 2002-04-17 EP disclosed
US-5571506-A AROMATIC ALDEHYDE OLIGOMERS FOR TREATMENT OF CARDIOVASCULAR DISORDERS, BONE METABOLISM, ANTILIPEMIC AGENTS AND GASTROINTESTINAL DISORDERS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-11-05 US disclosed
EP-0585371-A4 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE POULENC RORER INT (US) 1994-07-13 EP disclosed
EP-0585371-A1 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1994-03-09 EP disclosed
WO-1993000357-A1 THERAPEUTIC POLYPEPTIDES BASED ON VON WILLEBRAND FACTOR RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1993-01-07 WO disclosed
WO-1992020350-A1 AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-11-26 WO disclosed