Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534216 | 0.77 | JMJD6 (0.40) | TDP1KMT2ASLC6A2LMNAJMJD6 | |
| SCHEMBL7882044 | 0.75 | JMJD6 (0.52) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL7473475 | 0.75 | ALDH1A1 (0.44) | TDP1KMT2ALMNAL3MBTL1TSHR | |
| SCHEMBL25893352 | 0.73 | TDP1 (0.47) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL4857159 | 0.73 | L3MBTL1 (0.50) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL24070239 | 0.72 | TDP1 (0.46) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL7479483 | 0.72 | TDP1 (0.43) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL5648210 | 0.70 | SMN1; SMN2 (0.45) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL28740303 | 0.69 | JMJD6 (0.44) | TDP1KMT2ASLC6A2SLC6A3POLB | |
| SCHEMBL2152994 | 0.69 | L3MBTL1 (0.49) | TDP1KMT2ASLC6A2SLC6A3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883622-B1 | PROTON PUMP INHIBITOR | APOTEX INC (CA) | 2002-05-15 | — | — | EP | disclosed |
| US-6114537-A | 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS | APOTEX INC. (CA) | 2000-09-05 | — | — | US | disclosed |
| US-6093738-A | IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT | KARIMIAN KHASHAYAR (CA) | 2000-07-25 | — | — | US | disclosed |
| US-5677302-A | Thiadiazole compounds useful as proton pump inhibitors | APOTEX INC. (CA) | 1997-10-14 | — | — | US | disclosed |