Sugi Predict

Sugi Predict / Compounds / SCHEMBL7533779

SCHEMBL7533779

SCHEMBL7533779

CN(C)c1ccc(S(=O)(=O)c2cc(C(=O)O)c(F)c(F)c2F)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ MCL1 Q07820 3/20 0.39
▸ FLT1 P17948 2/20 0.37
▸ FLT4 P35916 2/20 0.37
▸ KDR P35968 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ CA12 O43570 1/20 0.36
▸ CA1 P00915 1/20 0.36
▸ CA2 P00918 1/20 0.36
▸ CA4 P22748 1/20 0.36
▸ CA9 Q16790 1/20 0.36
▸ MYC P01106 1/20 0.36
▸ MMP2 P08253 1/20 0.36
▸ MMP9 P14780 1/20 0.36
▸ MMP8 P22894 1/20 0.36
▸ MMP13 P45452 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7537143 0.81 ALDH1A1 (0.49) HPGDHSD17B10KDM4EALDH1A1ALOX15
SCHEMBL7540076 0.81 PKM (0.49) MMP2MMP9MMP8MMP13MMP3
SCHEMBL6676078 0.80 ALDH1A1 (0.49) HSD17B10ALDH1A1MCL1LMNACA1
SCHEMBL7533111 0.75 MAPK1 (0.48) KDM4ELMNAMEN1POLBKMT2A
SCHEMBL6265467 0.74 MCL1 (0.51) KDM4EALDH1A1MCL1LMNACA12
SCHEMBL7540459 0.74 TUBB1 (0.42) HPGDHSD17B10KDM4EALDH1A1LMNA
SCHEMBL6262823 0.73 MCL1 (0.50) KDM4EALDH1A1MCL1LMNACA12
SCHEMBL7541154 0.72 ALDH1A1 (0.56) HPGDHSD17B10KDM4EALDH1A1ALOX15
SCHEMBL7540365 0.69 ALDH1A1 (0.58) HPGDHSD17B10KDM4EALDH1A1ALOX15
SCHEMBL4575039 0.69 ALDH1A1 (0.79) HPGDHSD17B10KDM4EALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6388131-B2 Benzenesulfonamide compounds, which encompasses the compound batabulin (2-Fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene) TULARIK, INC. 2002-05-14 — — US disclosed
US-20020013496-A1 Benzene compounds as antiproliferative and cholesterol lowering agents AMGEN INC. 2002-01-31 — — US disclosed
US-6284923-B1 BENZENESULFONIMIDES FOR TREATMENT OF CANCER AND ANTICHOLESTEROL AGENTS TULARIK INC 2001-09-04 — — US disclosed
EP-1005453-A1 SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS TULARIK, INC. (US) 2000-06-07 — — EP disclosed
WO-1999010320-A1 SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS TULARIK INC. (US) 1999-03-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020013496-A1 Benzene compounds as antiproliferative and cholesterol lowering agents CYP46A1, TGFB1, NR1H2 HPGD 1932/4885HSD17B10 678/4885KDM4E 2230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.