SCHEMBL7533945

SCHEMBL7533945

COC(=O)c1sccc1NS(=O)(=O)c1ccc(F)c(F)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.69
LMNA P02545 1/20 0.69
TSHR P16473 1/20 0.69
KCNH2 Q12809 1/20 0.65
SLC10A6 Q3KNW5 1/20 0.57
PARP14 Q460N5 1/20 0.53
ALDH1A1 P00352 7/20 0.52
MAPT P10636 5/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
CYP1A2 P05177 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
ACLY P53396 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP3A4 P08684 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
KDM4E B2RXH2 3/20 0.47
PKM P14618 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1198776 0.90 TSHR (0.66) HPGDLMNATSHRKCNH2SLC10A6
SCHEMBL7531394 0.86 ACLY (0.67) HPGDLMNATSHRKCNH2ALDH1A1
SCHEMBL1199098 0.86 LMNA (0.78) HPGDLMNATSHRKCNH2SLC10A6
SCHEMBL7531669 0.85 ACLY (0.55) HPGDLMNATSHRKCNH2SLC10A6
Hydrochloric Acid SCHEMBL7531671 0.85 ACLY (0.66) HPGDLMNATSHRKCNH2ALDH1A1
SCHEMBL1198764 0.84 KCNH2 (0.67) HPGDLMNATSHRKCNH2SLC10A6
SCHEMBL1199804 0.83 HPGD (0.78) HPGDLMNATSHRKCNH2SLC10A6
SCHEMBL21999877 0.82 ACLY (0.74) HPGDLMNATSHRKCNH2SLC10A6
SCHEMBL1199735 0.82 LMNA (1.00) HPGDLMNATSHRKCNH2SLC10A6
SCHEMBL1200313 0.82 HPGD (0.80) HPGDLMNATSHRKCNH2SLC10A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO disclosed