SCHEMBL7534368

SCHEMBL7534368

O=C(O)C1Cc2ccccc2CN1Cc1ccccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.54
TDP1 Q9NUW8 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
POLB P06746 4/20 0.46
ACE P12821 3/20 0.44
DRD2 P14416 2/20 0.43
DRD3 P35462 1/20 0.43
KCNH2 Q12809 1/20 0.43
MMP3 P08254 1/20 0.43
MMP8 P22894 1/20 0.43
MMP13 P45452 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
ALDH1A1 P00352 2/20 0.41
LMNA P02545 1/20 0.41
DRD4 P21917 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CHEK1 O14757 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7534365 1.00 GRM2 (0.54) GRM2TDP1L3MBTL1POLBACE
SCHEMBL3302132 0.85 ACE (0.45) GRM2TDP1L3MBTL1POLBACE
SCHEMBL7478005 0.84 ACE (0.49) TDP1L3MBTL1POLBACEMMP3
SCHEMBL8336724 0.84 ACE (0.49) TDP1L3MBTL1POLBACEMMP3
SCHEMBL29870443 0.84 ACE (0.49) TDP1L3MBTL1POLBACEMMP3
SCHEMBL1817425 0.84 TDP1 (0.54) TDP1L3MBTL1POLBACEALDH1A1
SCHEMBL1817426 0.84 TDP1 (0.54) TDP1L3MBTL1POLBACEALDH1A1
SCHEMBL11559591 0.84 CYP1A2 (0.51) GRM2POLBACEDRD2DRD3
SCHEMBL8342126 0.82 MMP8 (0.58) TDP1L3MBTL1POLBACEMMP3
SCHEMBL8342131 0.82 MMP8 (0.58) TDP1L3MBTL1POLBACEMMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1045844-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2002-08-21 EP disclosed
EP-1045844-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2000-10-25 EP disclosed
US-5932590-A PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION MERCK & CO., INC. (US) 1999-08-03 US disclosed
WO-1999028314-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-06-10 WO disclosed