SCHEMBL8342131

SCHEMBL8342131

O=C(O)C1Cc2ccccc2CN1Cc1ccc(Cl)cc1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 7/20 0.58
MMP3 P08254 5/20 0.58
MMP13 P45452 1/20 0.58
TDP1 Q9NUW8 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
DRD4 P21917 1/20 0.53
POLB P06746 1/20 0.49
PPARD Q03181 2/20 0.48
PPARA Q07869 2/20 0.48
PPARG P37231 1/20 0.48
GRM7 Q14831 1/20 0.48
CYP19A1 P11511 1/20 0.47
ACE P12821 2/20 0.45
CFTR P13569 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8342126 1.00 MMP8 (0.58) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL8336724 0.91 ACE (0.49) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL7478005 0.91 ACE (0.49) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL29870443 0.91 ACE (0.49) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL7537137 0.87 POLB (0.48) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL7539116 0.87 POLB (0.48) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL7537140 0.87 POLB (0.48) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL6920302 0.84 HDAC8 (0.53) MMP3TDP1L3MBTL1POLB
SCHEMBL7534368 0.82 GRM2 (0.54) MMP8MMP3MMP13TDP1L3MBTL1
SCHEMBL7534365 0.82 GRM2 (0.54) MMP8MMP3MMP13TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5932590-A PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION MERCK & CO., INC. (US) 1999-08-03 US disclosed