Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.79 |
| ▸ | MMP2 | P08253 | 6/20 | 0.79 |
| ▸ | MMP3 | P08254 | 9/20 | 0.71 |
| ▸ | MMP1 | P03956 | 8/20 | 0.71 |
| ▸ | MMP7 | P09237 | 5/20 | 0.71 |
| ▸ | MMP13 | P45452 | 4/20 | 0.71 |
| ▸ | MMP8 | P22894 | 7/20 | 0.58 |
| ▸ | MMP12 | P39900 | 3/20 | 0.56 |
| ▸ | MMP14 | P50281 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534610 | 1.00 | MMP9 (0.79) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7533393 | 0.99 | MMP9 (0.80) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7533387 | 0.99 | MMP9 (0.80) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7568599 | 0.94 | MMP1 (0.75) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7568594 | 0.94 | MMP1 (0.75) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7531686 | 0.93 | MMP1 (0.73) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7531694 | 0.93 | MMP1 (0.73) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL31086908 | 0.92 | MMP2 (0.93) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7923015 | 0.88 | MMP1 (0.75) | MMP9MMP2MMP3MMP1MMP7 | |
| SCHEMBL7923021 | 0.88 | MMP1 (0.75) | MMP9MMP2MMP3MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | claimed |
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |