Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | IDE | P14735 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539138 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAMAPTKDM4EHTT | |
| SCHEMBL7534511 | 0.84 | ALDH1A1 (0.51) | MAPK1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL6068038 | 0.83 | LMNA (0.49) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL7251252 | 0.83 | MAPT (0.52) | MAPK1SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL7247636 | 0.81 | DYRK1A (0.51) | LMNARAB9ANPC1DYRK1A | |
| SCHEMBL7534938 | 0.81 | LMNA (0.47) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL1842323 | 0.81 | NPC1 (0.52) | MAPK1SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL15265867 | 0.81 | KMT2A (0.40) | SMN1; SMN2LMNAMAPTKDM4ERAD52 | |
| SCHEMBL7540147 | 0.80 | KMT2A (0.55) | MAPK1SMN1; SMN2LMNAMAPTHTT | |
| Hydrochloric Acid SCHEMBL1844041 | 0.80 | NPC1 (0.51) | MAPK1SMN1; SMN2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1422262-A | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors | ABBOTT GMBH & CO KG (DE) | 2003-06-04 | — | — | CN | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |