Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539138 | 0.84 | SMN1; SMN2 (0.48) | KMT2ASMN1; SMN2ALDH1A1HTTCA2 | |
| SCHEMBL7546425 | 0.82 | RAB9A (0.43) | KMT2ASMN1; SMN2ALDH1A1CYP3A4TSHR | |
| SCHEMBL7535208 | 0.80 | MAPK1 (0.50) | KMT2ASMN1; SMN2CYP3A4HTTDYRK1A | |
| SCHEMBL7534511 | 0.80 | ALDH1A1 (0.51) | KMT2ASMN1; SMN2ALDH1A1HTTDYRK1A | |
| SCHEMBL7537748 | 0.79 | PGK1 (0.43) | KMT2ASMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL6068038 | 0.79 | LMNA (0.49) | KMT2ASMN1; SMN2MAPTRAB9ALMNA | |
| SCHEMBL31219325 | 0.78 | HTT (0.66) | KMT2ASMN1; SMN2ALDH1A1CYP3A4TSHR | |
| SCHEMBL22130278 | 0.78 | HTT (0.66) | KMT2ASMN1; SMN2ALDH1A1CYP3A4TSHR | |
| SCHEMBL14979027 | 0.77 | HTT (0.54) | KMT2ASMN1; SMN2ALDH1A1CYP3A4TSHR | |
| SCHEMBL7534938 | 0.77 | LMNA (0.47) | KMT2ASMN1; SMN2MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |