SCHEMBL7536038

SCHEMBL7536038

[CH]=Cc1ccc(Cl)cc1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.60
TP53 P04637 1/20 0.48
MAPT P10636 3/20 0.46
GRIN2D O15399 2/20 0.46
GRIN3B O60391 2/20 0.46
GRIN1 Q05586 2/20 0.46
GRIN2A Q12879 2/20 0.46
GRIN2B Q13224 2/20 0.46
GRIN2C Q14957 2/20 0.46
GRIN3A Q8TCU5 2/20 0.46
GABRA1 P14867 1/20 0.46
GABRG2 P18507 1/20 0.46
GABRB3 P28472 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
AMY1A P0DUB6 1/20 0.44
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
TSHR P16473 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2582169 0.80 TDP1 (0.60) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL2097650 0.79 TDP1 (0.65) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL8580636 0.77 TDP1 (0.62) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL9996581 0.76 TDP1 (0.40) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL9996753 0.76 MAOA (0.40) TDP1MAPTCYP3A4NPC1RAB9A
SCHEMBL2582167 0.75 TDP1 (0.60) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL7831326 0.75 TDP1 (0.60) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL11454521 0.75 TDP1 (0.60) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL7413769 0.75 TDP1 (0.60) TDP1TP53MAPTGRIN2DGRIN3B
SCHEMBL109034 0.75 TDP1 (0.60) TDP1TP53MAPTGRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376548-B1 FUNGICIDES; HERBICIDES; INSECTICIDES ROHM AND HAAS COMPANY 2002-04-23 US claimed
WO-1999052936-A2 ARGININE PEPTIDE ANALOGS USEFUL AS FIBROBLAST GROWTH FACTOR ANTAGONISTS EISAI CO., LTD. (JP) 1999-10-21 WO claimed
CN-110432281-A A kind of application of the Stilbene analog of the ring structure containing thiazole as fungicide UNIV ZHEJIANG TECHNOLOGY 2019-11-12 CN disclosed
CN-110407767-A The Stilbene analog and its synthetic method of a kind of ring structure containing thiazole and application UNIV ZHEJIANG TECHNOLOGY 2019-11-05 CN disclosed
US-9822128-B1 Substituted spirooxindoles KING SAUD UNIVERSITY (SA) 2017-11-21 US disclosed
EP-0711760-B1 METHOD OF ALKYLATING TRIAZINE DERIVATIVE NISSAN CHEMICAL IND LTD (JP) 2002-05-15 EP disclosed
US-6376548-B1 FUNGICIDES; HERBICIDES; INSECTICIDES ROHM AND HAAS COMPANY 2002-04-23 US disclosed
EP-0882720-B1 METHODS FOR MODIFYING 1,3,5-TRIAZINE DERIVATIVES NISSAN CHEMICAL IND LTD (JP) 2001-08-22 EP disclosed
WO-2001056358-A2 ENHANCED PROPERTIED PESTICIDES ROHM AND HAAS COMPANY (US) 2001-08-09 WO disclosed
CN-1061649-C Method for modifying 1,3,5-triazine derivatives NISSAN CHEMICAL IND LTD (JP) 2001-02-07 CN disclosed
US-6130332-A USING A GROUP 8 METAL CATALYST AND ALDEHYDES OR KETONE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2000-10-10 US disclosed
WO-1999052936-A2 ARGININE PEPTIDE ANALOGS USEFUL AS FIBROBLAST GROWTH FACTOR ANTAGONISTS EISAI CO., LTD. (JP) 1999-10-21 WO disclosed
CN-1206409-A Method for modifying 1,3, 5-triazine derivative NISSAN CHEMICAL IND LTD (JP) 1999-01-27 CN disclosed
EP-0882720-A1 METHODS FOR MODIFYING 1,3,5-TRIAZINE DERIVATIVES NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1998-12-09 EP disclosed
US-5792867-A Method of alkylating of triazine derivatives NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-08-11 US disclosed
EP-0760369-A1 PROCESS FOR ALKYLATING TRIAZINE DERIVATIVE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1997-03-05 EP disclosed
EP-0711760-A1 METHOD OF ALKYLATING TRIAZINE DERIVATIVE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1996-05-15 EP disclosed
CN-1114834-A antidiabetic agent OTSUKA PHARMA CO LTD (JP) 1996-01-10 CN disclosed
EP-0670831-A1 QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-09-13 EP disclosed
WO-1995009159-A1 QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1995-04-06 WO disclosed