Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536657 | 0.72 | HCAR2 (0.33) | — | |
| SCHEMBL473739 | 0.70 | PDE5A (0.47) | PDE5AALDH1A1 | |
| 8-Aminoguanine SCHEMBL5513824 | 0.60 | PNP (0.77) | KDM4EALDH1A1KMT2AHSD17B10MEN1 | |
| SCHEMBL10421279 | 0.58 | PNP (0.54) | KDM4EALDH1A1KMT2AHSD17B10MEN1 | |
| SCHEMBL8905860 | 0.58 | PNP (0.49) | FGFR1FGFR2 | |
| SCHEMBL5133747 | 0.58 | PDE5A (0.51) | PDE5AALDH1A1 | |
| SCHEMBL14321806 | 0.56 | PNP (0.44) | ALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL236952 | 0.53 | MAPT (0.36) | SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL21905156 | 0.51 | HSD17B10 (0.36) | ALDH1A1HSD17B10 | |
| Uric Acid SCHEMBL2786719 | 0.51 | MAPT (0.53) | KDM4EALDH1A1KMT2ACASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684822-B1 | CARBOCYCLIC DEOXYGUANOSINE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS | SOUTHERN RES INST (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6080746-A | ADMINISTERING PURINE DERIVATIVE FOR PROPHYLAXIS AND TREATMENT OF CYTOMEGALO VIURS INFECTIONS IN HUMANS | SOUTHERN RESEARCH INSTITUTE | 2000-06-27 | — | — | US | disclosed |
| US-6001840-A | A SUBSTANTIAL MOLAR EXCESS OF THE D-STEREOISOMER OF 2'CDG OVER THE L-STEREOISOMER. | SOUTHERN RESEARCH INSTITUTE (US) | 1999-12-14 | — | — | US | disclosed |
| US-5718922-A | Intravitreal microsphere drug delivery and method of preparation | SCHEPENS EYE RESEARCH INSTITUTE, INC. (US) | 1998-02-17 | — | — | US | disclosed |
| US-5659021-A | Chiral glycerol derivatives | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1996038133-A1 | INTRAVITREAL MICROSPHERE DRUG DELIVERY AND METHOD OF PREPARATION | SCHEPENS EYE RESEARCH INSTITUTE, INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| EP-0684822-A4 | — | — | 1996-01-10 | — | — | EP | disclosed |
| EP-0684822-A1 | METHODS OF TREATMENT OF VIRAL INFECTIONS USING CARBOCYCLIC DEOXYGUANOSINE ANALOGS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994018979-A2 | METHODS OF TREATMENT OF VIRAL INFECTIONS USING CARBOCYCLIC DEOXYGUANOSINE ANALOGS | SOUTHERN RESEARCH INSTITUTE (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0471057-A4 | METHODS AND COMPOSITIONS FOR THE PROPHYLAXIS AND TREATMENT OF CYTOMEGALOVIRUS INFECTIONS | — | 1992-11-19 | — | — | EP | disclosed |
| EP-0471057-A1 | METHODS AND COMPOSITIONS FOR THE PROPHYLAXIS AND TREATMENT OF CYTOMEGALOVIRUS INFECTIONS | VIRACHEM, INC. (US) | 1992-02-19 | — | — | EP | disclosed |
| WO-1991013549-A1 | METHODS AND COMPOSITIONS FOR THE PROPHYLAXIS AND TREATMENT OF CYTOMEGALOVIRUS INFECTIONS | VIRACHEM, INC. (US) | 1991-09-19 | — | — | WO | disclosed |
| US-4849412-A | PAPAVERINE COMPOUND, NUCLEOSIDE ANALOG | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1989-07-18 | — | — | US | disclosed |