SCHEMBL473739

SCHEMBL473739

CCOCN(O)c1nc2nc[nH]c2c(=O)[nH]1

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 1/20 0.47
PNP P00491 1/20 0.44
XDH P47989 6/20 0.44
GDA Q9Y2T3 1/20 0.44
GRIA1 P42261 1/20 0.39
GRIA2 P42262 1/20 0.39
GRIA3 P42263 1/20 0.39
GRIA4 P48058 1/20 0.39
ALDH1A1 P00352 1/20 0.39
POLA1 P09884 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9275484 0.77 PNP (0.48) PDE5APNPXDHGDAGRIA1
SCHEMBL5323947 0.77 PNP (0.48) PDE5APNPXDHGDAGRIA1
SCHEMBL29138706 0.76 PNP (0.47) PDE5APNPXDHGDAGRIA1
SCHEMBL595204 0.74 PNP (0.57) PNPXDHGDAGRIA1GRIA2
Hydrochloric Acid SCHEMBL17186227 0.73 PNP (0.56) PNPXDHGDAGRIA1GRIA2
Hydrochloric Acid SCHEMBL17186358 0.73 PNP (0.56) PNPXDHGDAGRIA1GRIA2
SCHEMBL5133747 0.73 PDE5A (0.51) PDE5APNPXDHGDAGRIA1
SCHEMBL2435286 0.72 GDA (0.57) PNPXDHGDAGRIA1GRIA2
SCHEMBL37959 0.72 PNP (0.44) PDE5APNPXDHGDAGRIA1
SCHEMBL27762591 0.72 XDH (0.50) PDE5APNPXDHGDAPOLA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 241 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011056630-A2 SMALL MOLECULE INHIBITORS OF HEPATITIS C VIRUS TRUSTEES OF BOSTON UNIVERSITY (US) 2011-05-12 WO claimed
EP-4735462-A1 COMPOUNDS AND USES THEREFOR GLYCOSYNNOVATIONS PTY LTD (AU) 2026-05-06 EP disclosed
US-20250195501-A1 CELL ENTRY-MODULATING AGENTS AND USES THEREFOR GRIFFITH UNIVERSITY (AU) 2025-06-19 US disclosed
US-20250144066-A1 Prevention and Treatment of Parasitic Infections BARANOWITZ STEVEN (US) 2025-05-08 US disclosed
WO-2025064458-A1 PREVENTION AND TREATMENT OF VIRAL INFECTIONS BARANOWITZ STEVEN (US) 2025-03-27 WO disclosed
US-12226392-B2 Prevention and treatment of viral infections BARANOWITZ STEVEN (US) 2025-02-18 US disclosed
WO-2025000059-A1 COMPOUNDS AND USES THEREFOR Glycosynnovations Pty Ltd (AU) 2025-01-02 WO disclosed
US-20240299337-A1 Prevention and Treatment of Viral Infections BARANOWITZ STEVEN (US) 2024-09-12 US disclosed
US-12011429-B2 Prevention and treatment of viral infections BARANOWITZ STEVEN (US) 2024-06-18 US disclosed
US-20240066004-A1 Prevention and Treatment of Viral Infections BARANOWITZ STEVEN (US) 2024-02-29 US disclosed
US-20050158449-A1 Method and apparatus for coating of substrates Surmodics Coatings, LLC 2005-07-21 US disclosed
US-20050136483-A1 Nanodevices employing combinatorial artificial receptors RECEPTORS LLC (US) 2005-06-23 US disclosed
WO-2005053835-A2 ARTIFICIAL RECEPTORS INCLUDING GRADIENTS RECEPTORS LLC (US) 2005-06-16 WO disclosed
WO-2005024382-A9 NANODEVICES EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS RECEPTORS LLC (US) 2005-06-09 WO disclosed
US-20050106630-A1 Building blocks for artificial receptors RECEPTORS LLC (US) 2005-05-19 US disclosed
WO-2005024382-A2 NANODEVICES EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS RECEPTORS LLC (US) 2005-03-17 WO disclosed
WO-2005024433-A2 BUILDING BLOCKS FOR ARTIFICIAL RECEPTORS RECEPTORS LLC (US) 2005-03-17 WO disclosed
EP-1309360-A2 MEDICAMENT INCORPORATION MATRIX SurModics, Inc. (US) 2003-05-14 EP disclosed
US-20020041899-A1 Medicament incorporation matrix Surmodics Coatings, LLC 2002-04-11 US disclosed
WO-2002013871-A2 MEDICAMENT INCORPORATION MATRIX SURMODICS, INC. (US) 2002-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250195501-A1 CELL ENTRY-MODULATING AGENTS AND USES THEREFOR ACE2, ACE, TMPRSS2 PDE5A 2780/4885PNP 1477/4885XDH 1697/4885
US-12011429-B2 Prevention and treatment of viral infections MAVS, HAVCR2, NEU4 PDE5A 2629/4885PNP 106/4885XDH 140/4885
US-20250144066-A1 Prevention and Treatment of Parasitic Infections EPX, CTSA, SERPINB1 PDE5A 1428/4885PNP 404/4885XDH 310/4885
US-20020041899-A1 Medicament incorporation matrix COL14A1, MATR3, ECPAS PDE5A 4358/4885PNP 3921/4885XDH 1706/4885
US-12226392-B2 Prevention and treatment of viral infections MAVS, HAVCR2, MTREX PDE5A 3348/4885PNP 295/4885XDH 525/4885
US-20240299337-A1 Prevention and Treatment of Viral Infections MAVS, HAVCR2, NEU4 PDE5A 2629/4885PNP 106/4885XDH 140/4885
US-20240066004-A1 Prevention and Treatment of Viral Infections MAVS, HAVCR2, NEU4 PDE5A 2629/4885PNP 106/4885XDH 140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.