Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5391071 | 0.89 | PGR (0.39) | CA12CA1CA9UGT2B17PREP | |
| SCHEMBL14518499 | 0.89 | PGR (0.39) | CA12CA1CA9UGT2B17PREP | |
| SCHEMBL14518498 | 0.84 | ACHE (0.53) | ACHECA12CA1CA9PREP | |
| SCHEMBL1478135 | 0.78 | MTNR1B (0.51) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL6805525 | 0.78 | MTNR1B (0.51) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL6797543 | 0.78 | MTNR1B (0.51) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL14518500 | 0.78 | CA12 (0.34) | ACHECA12CA1CA9MTNR1B | |
| SCHEMBL22032597 | 0.73 | CA12 (0.38) | CA12CA1CA9PREP | |
| SCHEMBL7259713 | 0.73 | HCRTR1 (0.39) | ACHE | |
| SCHEMBL7715113 | 0.73 | HCRTR1 (0.39) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931086-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2002-05-02 | — | — | EP | disclosed |
| US-6133240-A | INHIBITION OF SELECTINS, AND THUS OF CELL ADHESION | DARWIN DISCOVERY, LTD. (GB) | 2000-10-17 | — | — | US | disclosed |