SCHEMBL7536952

SCHEMBL7536952

COc1ccccc1CN1CCOc2cc(N)ccc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.44
SLC6A4 P31645 1/20 0.44
KCNH2 Q12809 1/20 0.41
PKM P14618 1/20 0.41
SCN9A Q15858 1/20 0.40
DRD2 P14416 1/20 0.40
HTR2B P41595 1/20 0.40
NR3C1 P04150 1/20 0.39
PGR P06401 1/20 0.39
NR3C2 P08235 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19859151 0.81 LMNA (0.47) PKMHDAC3HDAC4HDAC1HDAC7
SCHEMBL14641696 0.80 HTR1A (0.39) HTR1ASLC6A4KCNH2PKMDRD2
SCHEMBL23768823 0.78 SCN9A (0.49) SCN9AHDAC1HDAC6KMT2AGAA
SCHEMBL31490291 0.78 SCN9A (0.49) SCN9AHDAC1HDAC6KMT2AGAA
SCHEMBL5519023 0.78 SMN1; SMN2 (0.45) HDAC1HDAC6TAAR1SIGMAR1GAA
SCHEMBL12107993 0.77 HTR2C (0.44) HTR1ASLC6A4KCNH2PKMDRD2
SCHEMBL2824174 0.77 BRD4 (0.46) MEN1KMT2AKDM4EHSD17B10
SCHEMBL16896933 0.76 HTR2A (0.38) HTR1ASLC6A4KCNH2DRD2NR3C1
SCHEMBL5516550 0.75 NR3C1 (0.41) NR3C1PGRMEN1KMT2AKDM4E
SCHEMBL8238626 0.75 GRM5 (0.44) HTR1ASLC6A4KCNH2KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001016139-A9 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARM INC (US) 2002-09-19 WO disclosed
EP-1212330-A1 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 2002-06-12 EP disclosed
WO-2001016139-A1 ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 2001-03-08 WO disclosed