Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 4/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558669 | 0.80 | MGAM (0.33) | — | |
| SCHEMBL6561204 | 0.75 | HIF1A (0.44) | HIF1ADRD3DRD2ADRB2HTR1A | |
| SCHEMBL23746417 | 0.73 | HIF1A (0.52) | KCNE1KCNQ1HIF1AHTR2AAKR1B1 | |
| SCHEMBL6559589 | 0.71 | TRPV1 (0.52) | KCNE1KCNQ1TRPV1 | |
| SCHEMBL9692756 | 0.69 | HIF1A (0.37) | KCNE1KCNQ1HIF1AHTR2AAKR1B1 | |
| SCHEMBL9692570 | 0.69 | KCNE1 (0.38) | KCNE1KCNQ1HIF1AHTR2AAKR1B1 | |
| SCHEMBL6561014 | 0.69 | KCNE1 (0.48) | KCNE1KCNQ1KCND3TRPV1 | |
| Hydrochloric Acid SCHEMBL9690368 | 0.68 | HIF1A (0.36) | KCNE1KCNQ1HIF1AHTR2ADRD2 | |
| SCHEMBL9692444 | 0.68 | HIF1A (0.39) | KCNE1KCNQ1HIF1AAKR1B1OPRM1 | |
| SCHEMBL19894360 | 0.68 | KCNE1 (0.39) | KCNE1KCNQ1AKR1B1CA2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |