Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 10/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 10/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559589 | 0.71 | TRPV1 (0.52) | KCNE1KCNQ1CYP3A4TRPV1 | |
| SCHEMBL7536992 | 0.69 | KCNE1 (0.43) | KCNE1KCNQ1KCND3TRPV1 | |
| SCHEMBL6559512 | 0.66 | TRPV1 (0.52) | KCNE1KCNQ1TRPV1 | |
| SCHEMBL6560802 | 0.65 | TRPV1 (0.51) | KCNE1KCNQ1TRPV1 | |
| SCHEMBL6559963 | 0.63 | TRPV1 (0.42) | TRPV1 | |
| SCHEMBL6558722 | 0.62 | KCNE1 (0.48) | KCNE1KCNQ1CYP3A4TRPV1 | |
| SCHEMBL8477357 | 0.61 | KCNE1 (0.47) | KCNE1KCNQ1TRPV1KCNA5 | |
| SCHEMBL6559271 | 0.60 | KCNE1 (0.61) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 | |
| SCHEMBL6559266 | 0.60 | KCNE1 (0.52) | KCNE1KCNQ1CYP3A4TRPV1 | |
| SCHEMBL6558672 | 0.59 | TRPV1 (0.49) | KCNE1KCNQ1CYP3A4TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |