Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540150 | 0.84 | MAPT (0.58) | MAPTLMNAALDH1A1MAPK1ABCC9 | |
| SCHEMBL7533321 | 0.80 | LMNA (0.60) | MAPTLMNAALDH1A1MAPK1SCN9A | |
| SCHEMBL6678633 | 0.80 | ALDH1A1 (0.60) | MAPTTDP1LMNAALDH1A1GFER | |
| SCHEMBL6681272 | 0.80 | MAPT (0.55) | MAPTTDP1LMNAALDH1A1GFER | |
| SCHEMBL6675727 | 0.80 | ALDH1A1 (0.57) | MAPTTDP1LMNAALDH1A1GFER | |
| SCHEMBL7533132 | 0.78 | LMNA (0.50) | MAPTLMNAALDH1A1ABCC9ABCC8 | |
| SCHEMBL7537146 | 0.78 | CA12 (0.48) | MAPTLMNAALDH1A1ABCC9ABCC8 | |
| SCHEMBL5718766 | 0.77 | ALDH1A1 (0.73) | MAPTTDP1LMNAALDH1A1GFER | |
| SCHEMBL4884368 | 0.77 | TDP1 (0.65) | MAPTTDP1LMNAALDH1A1GFER | |
| SCHEMBL6674394 | 0.74 | SLC22A12 (0.49) | MAPTTDP1LMNAALDH1A1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020013496-A1 | Benzene compounds as antiproliferative and cholesterol lowering agents | AMGEN INC. | 2002-01-31 | — | — | US | claimed |
| EP-1005453-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK, INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999010320-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK INC. (US) | 1999-03-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013496-A1 | Benzene compounds as antiproliferative and cholesterol lowering agents | CYP46A1, TGFB1, NR1H2 | MAPT 2283/4885TDP1 1692/4885LMNA 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.