Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30962517 | 0.85 | — | — | |
| SCHEMBL133569 | 0.81 | — | — | |
| Ammonia Solution, Strong SCHEMBL6052085 | 0.79 | — | — | |
| SCHEMBL446293 | 0.79 | — | — | |
| SCHEMBL18229695 | 0.69 | LMNA (0.34) | HDAC6HDAC4HDAC2HDAC8HDAC1 | |
| Imidazole SCHEMBL25324984 | 0.68 | ALDH1A1 (0.34) | — | |
| SCHEMBL10521524 | 0.66 | — | — | |
| Ammonia Solution, Strong SCHEMBL6052142 | 0.64 | — | — | |
| SCHEMBL14448972 | 0.55 | — | — | |
| SCHEMBL31737178 | 0.52 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1930143-B | MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles | JANSSEN PHARMACEUTICA NV | 2012-04-04 | — | — | CN | disclosed |
| CN-1930143-A | MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles | JANSSEN PHARMACEUTICA NV (BE) | 2007-03-14 | — | — | CN | disclosed |
| EP-1202731-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1144385-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005390-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000042022-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |