Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855812 | 0.93 | CHRNB2 (0.37) | NPC1RAB9AMEN1KMT2ACHRNB2 | |
| SCHEMBL6856200 | 0.93 | CHRNB2 (0.37) | NPC1RAB9AMEN1KMT2ACHRNB2 | |
| SCHEMBL6855285 | 0.84 | KMT2A (0.37) | NPC1RAB9AMEN1KMT2ACHRNB2 | |
| SCHEMBL6850200 | 0.84 | KMT2A (0.37) | NPC1RAB9AMEN1KMT2ACHRNB2 | |
| SCHEMBL6999029 | 0.80 | KMT2A (0.34) | NPC1RAB9AMEN1KMT2ACHRNB2 | |
| SCHEMBL6999028 | 0.80 | KMT2A (0.34) | NPC1RAB9AMEN1KMT2ACHRNB2 | |
| SCHEMBL7463931 | 0.79 | PIK3R1 (0.34) | — | |
| SCHEMBL7463540 | 0.76 | ALDH1A1 (0.30) | MAPT | |
| SCHEMBL7507189 | 0.75 | RXFP1 (0.31) | MAPT | |
| SCHEMBL6850093 | 0.75 | KMT2A (0.36) | NPC1RAB9AMEN1KMT2ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022112-A9 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH AN EXCESS OF IL-12 PRODUCTION | WARNER LAMBERT CO (US) | 2002-06-06 | — | — | WO | disclosed |