Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | NT5E | P21589 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.61 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.58 |
| ▸ | GAPDH | P04406 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | STAT6 | P42226 | 1/20 | 0.58 |
| ▸ | PI4KA | P42356 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014081 | 0.88 | LMNA (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL3970946 | 0.88 | LMNA (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL5033515 | 0.88 | LMNA (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL899617 | 0.88 | LMNA (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL6663083 | 0.88 | LMNA (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL16555404 | 0.88 | LMNA (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL11481461 | 0.87 | LMNA (0.61) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL62505 | 0.87 | CYP2C19 (0.62) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL2424283 | 0.87 | LMNA (0.64) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL7535713 | 0.87 | HPGD (0.62) | LMNANT5EHIF1AADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288221-B1 | REPLACING NUCLEOSIDE WITH DIMETHOXYTRITYL, PHOSPHORAMIDITE, OR HALONUCLEOSIDE DERIVATIVE; ELECTROCHEMICAL OR PHOTOCHEMICAL DETECTION OF NUCLEIC ACID SEQUENCES | DUKE UNIVERSITY | 2001-09-11 | — | — | US | claimed |
| US-20020177695-A1 | Nucleic acid probes and methods | DUKE UNIVERSITY | 2002-11-28 | — | — | US | disclosed |
| WO-2002044196-A1 | METHODS AND REAGENTS FOR INTRODUCING A SULFHYDRYL GROUP INTO THE 5'-TERMINUS OF RNA | UNIVERSITY OF MASSACHUSETTS (US) | 2002-06-06 | — | — | WO | disclosed |
| US-6288221-B1 | REPLACING NUCLEOSIDE WITH DIMETHOXYTRITYL, PHOSPHORAMIDITE, OR HALONUCLEOSIDE DERIVATIVE; ELECTROCHEMICAL OR PHOTOCHEMICAL DETECTION OF NUCLEIC ACID SEQUENCES | DUKE UNIVERSITY | 2001-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177695-A1 | Nucleic acid probes and methods | NUDT1, NT5C3B, NT5C2 | LMNA 1665/4885NT5E 9/4885HIF1A 3396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.