Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536797 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1THRBHRH3 | |
| Hydrochloric Acid SCHEMBL7538691 | 0.85 | POLB (0.57) | SMN1; SMN2KDM4EALDH1A1THRBHRH3 | |
| SCHEMBL7544924 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1THRBHRH3 | |
| SCHEMBL7279730 | 0.82 | MEN1 (0.61) | SMN1; SMN2KDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL7536722 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EALDH1A1THRBHRH3 | |
| SCHEMBL7540035 | 0.81 | HRH3 (0.55) | SMN1; SMN2ALDH1A1HRH3HPGDKMT2A | |
| SCHEMBL7278718 | 0.79 | ALDH1A1 (0.62) | SMN1; SMN2KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL7538029 | 0.79 | HRH3 (0.44) | SMN1; SMN2KDM4EALDH1A1THRBHRH3 | |
| SCHEMBL7538936 | 0.78 | POLB (0.41) | SMN1; SMN2KDM4EALDH1A1THRBHRH3 | |
| SCHEMBL7282287 | 0.78 | NPC1 (0.58) | SMN1; SMN2KDM4EALDH1A1THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1211249-A1 | NOVEL THIAZINE OR PYRAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-05 | — | — | EP | disclosed |