Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254145 | 0.79 | ACHE (0.41) | NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5392701 | 0.78 | SCN10A (0.32) | PPARASCN10APPARG | |
| SCHEMBL18260863 | 0.78 | APP (0.41) | SCN10A | |
| SCHEMBL15718370 | 0.78 | ALDH1A1 (0.41) | PPARANPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL3161252 | 0.78 | MAOB (0.40) | SCN10AALDH1A1 | |
| SCHEMBL5675865 | 0.77 | TAAR1 (0.46) | ALDH1A1PPARG | |
| SCHEMBL503302 | 0.76 | SLC6A2 (0.37) | PPARANPC1ALDH1A1MAPTHPGD | |
| SCHEMBL1353598 | 0.73 | TAAR1 (0.30) | — | |
| SCHEMBL5139988 | 0.71 | LOXL2 (0.47) | ALDH1A1MAPK1 | |
| SCHEMBL5156847 | 0.69 | CA1 (0.55) | NPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448294-B1 | SUCH AS 1,5-DICHORO- OR 5-(4-(2-(DIMETHYLAMINO)ETHOXY)PHENYL) SUBSTITUTED -6-(4-HYDROXYPHENYL)-2-NAPHTHALENOLS; ANTIUTERO-TROPHIC AND REPLACEMENT TREATMENT OF SYMPTOMS LINKED TO MENOPAUSE PARTICULARLY OSTEOPOROSIS | AVENTIS PHARMA S.A. (FR) | 2002-09-10 | — | — | US | disclosed |
| EP-0880496-B1 | BIPHENYL COMPOUNDS AND USE THEREOF AS OESTROGENIC AGENTS | AVENTIS PHARMA SA (FR) | 2002-05-29 | — | — | EP | disclosed |