Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546664 | 0.88 | PPARA (0.45) | ALDH1A1KDM4EPPARAFFAR1PPARG | |
| SCHEMBL7547501 | 0.84 | PPARA (0.49) | MAPTPPARAFFAR1PPARG | |
| SCHEMBL5376653 | 0.83 | RAB9A (0.44) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL7540590 | 0.83 | RAB9A (0.43) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL6589744 | 0.83 | MAPT (0.42) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL7543020 | 0.82 | ALDH1A1 (0.43) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL5379428 | 0.82 | RAB9A (0.46) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL7543023 | 0.81 | ALDH1A1 (0.42) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL5372050 | 0.81 | RAB9A (0.46) | ALDH1A1RAB9ANPC1MAPTTSHR | |
| SCHEMBL5376645 | 0.81 | RAB9A (0.45) | ALDH1A1RAB9ANPC1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |