Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.51 |
| ▸ | ITGAV | P06756 | 8/20 | 0.51 |
| ▸ | ADM2 | Q7Z4H4 | 4/20 | 0.36 |
| ▸ | CALCB | P10092 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545780 | 0.79 | ITGB3 (0.59) | ITGB3ITGA2BITGAV | |
| SCHEMBL7539970 | 0.77 | ITGB3 (0.46) | ITGB3ITGA2BITGAVHDAC8MAP2K2 | |
| SCHEMBL7543230 | 0.76 | ITGB3 (0.46) | ITGB3ITGA2BITGAVHDAC8 | |
| SCHEMBL7659474 | 0.74 | ITGB3 (0.49) | ITGB3ITGA2BITGAV | |
| SCHEMBL6419667 | 0.73 | ITGB3 (0.54) | ITGB3ITGA2BITGAV | |
| SCHEMBL6420692 | 0.73 | ITGB3 (0.54) | ITGB3ITGA2BITGAVHDAC8 | |
| SCHEMBL6418484 | 0.72 | ITGB3 (0.70) | ITGB3ITGA2BITGAV | |
| SCHEMBL7541901 | 0.72 | ITGB3 (0.51) | ITGB3ITGA2BITGAV | |
| SCHEMBL6418662 | 0.70 | ITGB3 (0.51) | ITGB3ITGA2BITGAV | |
| SCHEMBL7335166 | 0.70 | ITGB3 (0.49) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458784-B1 | PHARMACEUTICALLY ACTIVE BENZODIAZAPINE COMPOUNDS OF FORMULA (I) ARE DISCLOSED. THESE COMPOUNDS INHIBIT THE VITRONECTIN RECEPTOR AND ARE USEFUL FOR TREATMENT OF OSTEOPOROSIS. | SMITHKLINE BEECHAM CORPORATION | 2002-10-01 | — | — | US | disclosed |
| EP-0762882-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0762882-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1996000574-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |