Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.49 |
| ▸ | ITGAV | P06756 | 3/20 | 0.49 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539970 | 0.82 | ITGB3 (0.46) | ITGB3ITGA2BITGAVNAMPT | |
| SCHEMBL7543230 | 0.81 | ITGB3 (0.46) | ITGB3ITGA2BITGAVBRD4POLB | |
| SCHEMBL7333252 | 0.80 | ITGB3 (0.52) | ITGB3ITGA2BITGAVHPGD | |
| SCHEMBL7545503 | 0.80 | ITGB3 (0.47) | ITGB3ITGA2BITGAVBRD4NAMPT | |
| SCHEMBL7541901 | 0.80 | ITGB3 (0.51) | ITGB3ITGA2BITGAVRAB9ANPC1 | |
| SCHEMBL7545780 | 0.80 | ITGB3 (0.59) | ITGB3ITGA2BITGAVKMT2ARAB9A | |
| SCHEMBL2786534 | 0.79 | ITGB3 (0.52) | ITGB3ITGA2BITGAVMEN1KMT2A | |
| SCHEMBL2786598 | 0.79 | ITGB3 (0.52) | ITGB3ITGA2BITGAVMEN1KMT2A | |
| SCHEMBL7335166 | 0.78 | ITGB3 (0.49) | ITGB3ITGA2BITGAVMEN1KMT2A | |
| SCHEMBL6676170 | 0.78 | ITGB3 (0.56) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458784-B1 | PHARMACEUTICALLY ACTIVE BENZODIAZAPINE COMPOUNDS OF FORMULA (I) ARE DISCLOSED. THESE COMPOUNDS INHIBIT THE VITRONECTIN RECEPTOR AND ARE USEFUL FOR TREATMENT OF OSTEOPOROSIS. | SMITHKLINE BEECHAM CORPORATION | 2002-10-01 | — | — | US | disclosed |