Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12750810 | 0.88 | KDM4A (0.42) | MEN1KMT2ATSHRKDM4AKDM4C | |
| Hydrochloric Acid SCHEMBL25170217 | 0.86 | KDM4A (0.45) | MEN1KMT2ATSHRKDM4AKDM4C | |
| SCHEMBL4019745 | 0.81 | PHF8 (0.39) | MEN1KMT2ATSHRTDP1PKM | |
| SCHEMBL24346148 | 0.81 | MEN1 (0.33) | MEN1KMT2ATSHRTDP1PKM | |
| SCHEMBL23230291 | 0.79 | MEN1 (0.32) | MEN1KMT2ATSHR | |
| SCHEMBL5148500 | 0.79 | MEN1 (0.32) | MEN1KMT2ATSHRPRMT3 | |
| SCHEMBL5368106 | 0.78 | POLB (0.33) | MEN1KMT2ATSHR | |
| SCHEMBL754536 | 0.78 | PAOX (0.37) | MEN1KMT2ATSHR | |
| SCHEMBL7135223 | 0.77 | — | — | |
| SCHEMBL2536587 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266958-B1 | Antiviral agent | SHIONOGI & CO (JP) | 2017-03-15 | — | — | EP | disclosed |
| EP-1422218-B1 | ANTIVIRAL AGENT | SHIONOGI & CO (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7547722-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2009-06-16 | — | — | US | disclosed |
| US-7449489-B2 | Indolylalkylamino-methylidenecarbamate derivatives useful as GnRH antagonists | ASTRAZENECA AB (SE) | 2008-11-11 | — | — | US | disclosed |
| US-20080045517-A1 | 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH) | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
| US-7317010-B2 | Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone | ASTRAZENECA AB (SE) | 2008-01-08 | — | — | US | disclosed |
| US-7268158-B2 | 6H-THIENO [2,3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH) | ASTRAZENECA AB (SE) | 2007-09-11 | — | — | US | disclosed |
| US-7256188-B2 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists | ASTRAZENECA AB (SE) | 2007-08-14 | — | — | US | disclosed |
| US-20070185106-A1 | Pyrrole derivatives as gonadotropin releasing hormone (gnrh) antagonists | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| US-20070185185-A1 | Derivatives of thienopyrrole as gnrh antagonists | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| US-20070167428-A1 | Thienopyrroles as antagonists of gnrh | ASTRAZENECA AB (SE) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045517-A1 | 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH) | GNRHR, PRLHR, GHRHR | MEN1 761/4885KMT2A 1698/4885TSHR 20/4885 |
| US-20070185106-A1 | Pyrrole derivatives as gonadotropin releasing hormone (gnrh) antagonists | GNRHR, PRLHR, GHRHR | MEN1 356/4885KMT2A 1732/4885TSHR 26/4885 |
| US-20070167428-A1 | Thienopyrroles as antagonists of gnrh | GNRHR, PRLHR, TRHR | MEN1 923/4885KMT2A 1902/4885TSHR 9/4885 |
| US-20070185185-A1 | Derivatives of thienopyrrole as gnrh antagonists | GNRHR, PRLHR, TRHR | MEN1 880/4885KMT2A 1997/4885TSHR 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.