Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542204 | 0.87 | MAPK8 (0.39) | MAPK8MAPTIDO1POLBHTT | |
| SCHEMBL7664571 | 0.86 | NTRK1 (0.48) | MAPK8MAPTHTTLMNAHPGD | |
| SCHEMBL7539246 | 0.86 | NTRK1 (0.41) | MAPK8POLBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7545477 | 0.85 | PTPRC (0.44) | MAPK8MAPTPOLBHTTLMNA | |
| SCHEMBL7550361 | 0.84 | MAPK8 (0.43) | MAPK8MAPTIDO1HTTNPSR1 | |
| SCHEMBL7540773 | 0.80 | MAPK8 (0.39) | MAPK8MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL7655178 | 0.78 | PTPRC (0.49) | MAPK8MAPTIDO1HTTNPSR1 | |
| SCHEMBL7546778 | 0.78 | CCNE2 (0.43) | MAPK8MAPTHTTLMNACYP1A2 | |
| SCHEMBL9067875 | 0.78 | PTPRC (0.48) | MAPTHTTLMNATP53L3MBTL1 | |
| SCHEMBL7663521 | 0.76 | NTRK1 (0.45) | MAPK8MAPTIDO1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | claimed |
| EP-1187826-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000071532-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | claimed |
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |