SCHEMBL7546778

SCHEMBL7546778

CN(C)C(=O)Nc1scc(SCc2cccnc2)c1C(N)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNE2 O96020 1/20 0.43
CCNE1 P24864 1/20 0.43
CDK2 P24941 1/20 0.43
MAPK8 P45983 1/20 0.43
NTRK1 P04629 1/20 0.40
GFER P55789 5/20 0.38
HTT P42858 1/20 0.38
RECQL P46063 1/20 0.38
ALDH1A1 P00352 3/20 0.37
PKM P14618 1/20 0.37
MDM2 Q00987 1/20 0.37
LMNA P02545 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
TSHR P16473 1/20 0.36
ACVR2A P27037 1/20 0.36
TGFBR2 P37173 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7539246 0.87 NTRK1 (0.41) MAPK8NTRK1ALDH1A1CYP1A2CYP3A4
SCHEMBL7545477 0.87 PTPRC (0.44) MAPK8NTRK1GFERHTTALDH1A1
SCHEMBL7542204 0.81 MAPK8 (0.39) MAPK8NTRK1HTTALDH1A1LMNA
SCHEMBL7655178 0.81 PTPRC (0.49) MAPK8NTRK1GFERHTTRECQL
SCHEMBL7664571 0.81 NTRK1 (0.48) MAPK8NTRK1HTTALDH1A1LMNA
SCHEMBL7540773 0.79 MAPK8 (0.39) MAPK8NTRK1GFERHTTALDH1A1
SCHEMBL9067875 0.79 PTPRC (0.48) HTTALDH1A1PKMLMNATSHR
SCHEMBL7542984 0.78 NTRK1 (0.35) NTRK1GFERALDH1A1NPC1RAB9A
SCHEMBL7541519 0.78 MAPK8 (0.42) MAPK8HTTLMNACYP1A2CYP3A4
SCHEMBL7663521 0.78 NTRK1 (0.45) MAPK8NTRK1HTTALDH1A1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6380214-B1 THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES PFIZER INC. 2002-04-30 US claimed
US-6380214-B1 THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES PFIZER INC. 2002-04-30 US disclosed
EP-1187826-A1 HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS Pfizer Products Inc. (US) 2002-03-20 EP disclosed
WO-2000071532-A1 HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS PFIZER PRODUCTS INC. (US) 2000-11-30 WO disclosed