Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545477 | 0.88 | PTPRC (0.44) | NTRK1MAPK8MAPK10POLBKMT2A | |
| SCHEMBL7542204 | 0.87 | MAPK8 (0.39) | NTRK1MAPK8POLBKMT2AMEN1 | |
| SCHEMBL7546778 | 0.87 | CCNE2 (0.43) | NTRK1MAPK8KMT2AMEN1CYP1A2 | |
| SCHEMBL7664571 | 0.86 | NTRK1 (0.48) | NTRK1MAPK8KMT2AMEN1HPGD | |
| SCHEMBL7541519 | 0.86 | MAPK8 (0.42) | MAPK8MAPK10POLBCYP1A2CYP3A4 | |
| SCHEMBL7550361 | 0.84 | MAPK8 (0.43) | MAPK8MAPK9MAPK10KMT2AMEN1 | |
| SCHEMBL7542984 | 0.84 | NTRK1 (0.35) | NTRK1HPGDALDH1A1 | |
| SCHEMBL7546188 | 0.81 | SMN1; SMN2 (0.40) | NTRK1POLBKMT2ACYP1A2SMN1; SMN2 | |
| SCHEMBL7655178 | 0.81 | PTPRC (0.49) | NTRK1MAPK8KMT2AMEN1CYP1A2 | |
| SCHEMBL7540773 | 0.81 | MAPK8 (0.39) | NTRK1MAPK8MAPK10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | claimed |
| EP-1187826-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000071532-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | claimed |
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |