Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.48 |
| ▸ | PTPRG | P23470 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542204 | 0.90 | MAPK8 (0.39) | NTRK1ALDH1A1MEN1KMT2AMAPK8 | |
| SCHEMBL7545477 | 0.88 | PTPRC (0.44) | NTRK1ALDH1A1MEN1KMT2AMAPK8 | |
| SCHEMBL7655178 | 0.87 | PTPRC (0.49) | NTRK1PTPRGALDH1A1MEN1KMT2A | |
| SCHEMBL7550361 | 0.87 | MAPK8 (0.43) | ALDH1A1MEN1KMT2ATDP1MAPK8 | |
| SCHEMBL7539246 | 0.86 | NTRK1 (0.41) | NTRK1ALDH1A1MEN1KMT2AMAPK8 | |
| SCHEMBL7565785 | 0.86 | NTRK1 (0.41) | NTRK1PTPRGICAM1SELEALDH1A1 | |
| SCHEMBL7541519 | 0.86 | MAPK8 (0.42) | MAPK8LMNAHTTMAPTHPGD | |
| SCHEMBL7542984 | 0.86 | NTRK1 (0.35) | NTRK1PTPRGALDH1A1HPGD | |
| SCHEMBL7663521 | 0.83 | NTRK1 (0.45) | NTRK1PTPRGTSHRALDH1A1MEN1 | |
| SCHEMBL7540773 | 0.83 | MAPK8 (0.39) | NTRK1ALDH1A1MEN1KMT2AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | claimed |
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |