Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | NOS2 | P35228 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9445642 | 0.78 | NOS1 (0.46) | NOS1NOS2NOS3 | |
| SCHEMBL13576632 | 0.75 | NOS1 (0.47) | NOS1NOS2NOS3 | |
| SCHEMBL1133545 | 0.75 | NOS1 (0.52) | NOS1NOS2NOS3 | |
| SCHEMBL20477489 | 0.74 | FAAH (0.36) | NOS1NOS2 | |
| SCHEMBL20477488 | 0.74 | FAAH (0.36) | NOS1NOS2 | |
| SCHEMBL14246443 | 0.73 | NOS1 (0.46) | NOS1NOS2NOS3 | |
| SCHEMBL528992 | 0.73 | NOS1 (0.46) | NOS1NOS2NOS3 | |
| SCHEMBL21297485 | 0.73 | NOS1 (0.46) | NOS1NOS2NOS3 | |
| SCHEMBL20477496 | 0.73 | FAAH (0.35) | — | |
| SCHEMBL7157465 | 0.72 | NOS1 (0.44) | NOS1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002544196-A | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-1178967-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | claimed |
| WO-2000068201-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | claimed |