Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25575417 | 0.83 | RAB9A (0.48) | ALDH1A1HPGDPOLBPKMRAB9A | |
| SCHEMBL9188603 | 0.71 | ALDH1A1 (0.56) | ALDH1A1HPGDPOLBPKMTSHR | |
| SCHEMBL30341829 | 0.69 | POLB (0.71) | ALDH1A1HPGDPOLBPKMMEN1 | |
| SCHEMBL4402923 | 0.69 | POLB (0.71) | ALDH1A1HPGDPOLBPKMMEN1 | |
| SCHEMBL29838651 | 0.69 | ALDH1A1 (0.47) | ALDH1A1HPGDPOLBMEN1KMT2A | |
| SCHEMBL859822 | 0.69 | ALDH1A1 (0.47) | ALDH1A1HPGDPOLBMEN1KMT2A | |
| SCHEMBL6904886 | 0.68 | POLB (0.59) | ALDH1A1HPGDPOLBMEN1KMT2A | |
| SCHEMBL28751074 | 0.67 | POLB (0.69) | ALDH1A1HPGDPOLBPKMMEN1 | |
| SCHEMBL14950486 | 0.66 | POLB (0.56) | ALDH1A1HPGDPOLBMEN1KMT2A | |
| SCHEMBL10310217 | 0.66 | POLB (0.56) | ALDH1A1HPGDPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |