Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.87 |
| ▸ | MMP1 | P03956 | 19/20 | 0.87 |
| ▸ | MMP13 | P45452 | 19/20 | 0.87 |
| ▸ | MMP9 | P14780 | 4/20 | 0.76 |
| ▸ | MMP2 | P08253 | 1/20 | 0.76 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.65 |
| ▸ | MMP3 | P08254 | 2/20 | 0.65 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031323 | 1.00 | ADAM17 (0.87) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL3946332 | 0.88 | MMP1 (0.78) | ADAM17MMP1MMP13MMP9MMP2 | |
| Hydrochloric Acid SCHEMBL6507693 | 0.87 | MMP1 (0.77) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL2358255 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL3942486 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9MMP2 | |
| Propionamide SCHEMBL7428300 | 0.82 | ADAM17 (0.90) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL7493293 | 0.81 | MMP1 (0.90) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL12272905 | 0.79 | ADAM17 (0.86) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL7314816 | 0.79 | MMP1 (0.71) | ADAM17MMP1MMP13MMP9MMP2 | |
| SCHEMBL8051411 | 0.79 | MMP1 (0.86) | ADAM17MMP1MMP13MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |